7 Background Literature

The papers listed below were used as sources for this presentation. They are arranged under general topics that they address.

Proton pathway in the MoFe Protein

Dance, I. (2015). Activation of N2, the enzymatic way.  Zeitschrift für Anorganische und Allgemeine Chemie 641(1): 91-99.

Role of ATP hydrolysis  and phosphate release in Nitrogenase function

Duval, S., K. Danyal, S. Shaw, A. K. Lytle, D. R. Dean, B. M. Hoffman, E. Antony and L. C. Seefeldt (2013). Electron transfer precedes ATP hydrolysis during Niitrogenase catalysis. Proceedings of the National Academy of Sciences (USA)  110(41): 16414-16419.

Reviews of Nitrogenase  mechanisms

Harris et al. (2019). Mo-, V-, and Fe-Nitrogenase use a universal eight-electron reductive-elimiation mechanism to achieve N2 reduction. Biochemistry 58(30): 3293-3301

Hoffman, B. M., D. Lukoyanov, D. R. Dean and L. C. Seefeldt (2013). Nitrogenase: A draft mechanism. Accounts of Chemical Research 46(2): 587-595.

Hoffman, B. M., D. Lukoyanov, Z.-Y. Yang, D. R. Dean and L. C. Seefeldt (2014). Mechanism of nitrogen fixation by Nitrogenase: The next stage. Chemical Reviews 114(8): 4041-4062.

Rutledge, H. L. and F. A. Tezcan (2020). Electron Transfer in Nitrogenase. Chemical Reviews 120(12): 5158-5193.

Van Stappen, C., L. Decamps, G. E. Cutsail, R. Bjornsson, J. T. Henthorn, J. A. Birrell and S. Debeer (2020). The spectroscopy of Nitrogenases. Chemical Reviews 120(12): 5005-5081.

Interactions across the Nitrogenase complex

Huang, Q., M. Tokmina-Lukaszewska, L. E. Johnson, H. Kallas, B. Ginovska, J. W. Peters, L. C. Seefeldt, B. Bothner and S. Raugei (2021). Mechanical coupling in the Nitrogenase complex. PLOS Computational Biology 17(3): e1008719.

Classic paper describing the Lowe-Thorneley kinetic model

Lowe, D. J. and R. N. Thorneley (1984). The mechanism of Klebsiella pneumoniae Nitrogenase action. Pre-steady-state kinetics of H2 formation. Biochemical Journal 224(3): 877-886.

Janus Intermediate mechanistic details

Lukoyanov, D. A., M. D. Krzyaniak, D. R. Dean, M. R. Wasielewski, L. C. Seefeldt and B. M. Hoffman (2019). Time-resolved EPR study of H2 reductive elimination from the photoexcited Nitrogenase Janus E4(4H) intermediate. The Journal of Physical Chemistry B 123(41): 8823-8828.

Raugei, S., L. C. Seefeldt and B. M. Hoffman (2018). Critical computational analysis illuminates the reductive-elimination mechanism that activates Nitrogenase for N2 reduction. Proc. Natl.. Acad. Sci. (USA): 115(45):E10521-E10530.

 

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How Nitrogenase Works Copyright © 2022 by William J. Hickey. All Rights Reserved.

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